13. Feb, 2022
Omicron, očkování a neutralizační protilátky
Omicron’s message on vaccines: Boosting begets breadth
Duane R. Wesemann1,2,* 1Department of Medicine, Division of Allergy and Clinical Immunology, Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA 2Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA *Correspondence: dwesemann@bwh.harvard.edu https://doi.org/10.1016/j.cell.2022.01.006
In this issue of Cell, three studies confirm that SARS-CoV-2 Omicron strongly evades a key immune deffense—neutralizing antibodies. However, while one- or two-dose vaccine regimens fail to induce anti-Omicron neutralizing antibodies, a homologous third-dose booster rescues neutralization function in a way that highlights the adaptability of immune memory, where recalled immunity extends antibody reach across SARS-CoV-2 variants